2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140434
    t-Boc-Aminooxy-PEG5-azide 2250216-95-4
    t-Boc-Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. t-Boc-Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    t-Boc-Aminooxy-PEG5-azide
  • HY-140529
    N-Mal-N-bis(PEG2-acid) 2110449-02-8
    N-Mal-N-bis(PEG2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Mal-N-bis(PEG2-acid)
  • HY-140525
    N-(Azido-PEG2)-N-Boc-PEG4-acid 2093153-82-1
    N-(Azido-PEG2)-N-Boc-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Boc-PEG4-acid
  • HY-138354
    Pyrroline-5-carboxylate 2139-03-9
    Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pyrroline-5-carboxylate
  • HY-133070
    Tos-PEG5-C2-Boc 850090-10-7
    Tos-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG5-C2-Boc
  • HY-138522
    NHS-bis-PEG2-amide-Mal
    NHS-bis-PEG2-amide-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NHS-bis-PEG2-amide-Mal
  • HY-114661
    m-PEG4-Tos 62921-76-0 ≥98.0%
    m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277).
    m-PEG4-Tos
  • HY-133051
    Hydroxy-PEG5-acid 2079768-50-4 ≥98.0%
    Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG5-acid
  • HY-W125504
    AEEA-AEEA 1143516-05-5 99.12%
    AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    AEEA-AEEA
  • HY-140874
    Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane 1421933-29-0
    Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane
  • HY-130870
    Fmoc-NH-PEG11-CH2CH2COOH 3076038-46-2 98.53%
    Fmoc-NH-PEG11-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG11-CH2CH2COOH
  • HY-134512
    Aminooxy-PEG3-C2-thiol 1200365-63-4
    Aminooxy-PEG3-C2-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG3-C2-thiol
  • HY-140149
    Azido-PEG4-Val-Cit-PAB-OH 2055024-64-9 98.0%
    Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-Val-Cit-PAB-OH
  • HY-140642
    Aminooxy-PEG-OH (MW 2000)
    Aminooxy-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG-OH (MW 2000)
  • HY-140766
    Azido-PEG5-CH2CO2-NHS 2144777-77-3
    Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-CH2CO2-NHS
  • HY-141350
    S-acetyl-PEG4-propargyl 1422540-88-2
    S-acetyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG4-propargyl
  • HY-145245
    TLR4-IN-C34-C2-amide-C6-OH 99.62%
    TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
    TLR4-IN-C34-C2-amide-C6-OH
  • HY-130600
    HO-PEG17-OH 351342-04-6 98.94%
    HO-PEG17-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG17-OH
  • HY-130470
    Chloroacetamido-PEG4-C2-Boc 1365655-90-8
    Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Chloroacetamido-PEG4-C2-Boc
  • HY-141347
    S-acetyl-PEG4-Boc 1818294-26-6
    S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG4-Boc
PROTAC Linkers Isoform Comparison

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